After an action-packed but failed trip to Earth, the wolves and Astro head back into outer space, desperately in need of a well-earned rest. But their holiday on Vacation Planet is interrupted when they discover they’re being hunted by the greediest, deadliest and most insatiable beasts on Earth: GRANDMAS! They’re mad as heck and hungry for revenge – and as if that wasn’t bad enough, they can smell wolf-flesh!

A life-and-death struggle follows as Jim, Keith and Astro flee from planet to planet in an attempt to escape the Grandmas’ unusual methods of attack. What will happen when Subwoolfer runs out of places to hide? Will Jim and Keith manage to gather an army that can beat the grandmas? And is there anyone out there in the galaxy who can help them?